Once a sufficient understanding of the antibacterial target is obtained, we shall be able to conduct rational drug design based on inhibition of the RNA synthetases and so develop new drugs useful for combating bacterial infections. We plan to use a genetic approach to determine whether the development of inhibition is feasible for individual steps in the pathway of aa-tRNA synthesis. We plan to synthesize compounds designed to inhibit specific steps in the reaction catalyzed by RNA: aa-tRNA synthetase. Since the first day of app development, your experience onÂ .The overall goal of our research is to increase our understanding of the biosynthesis, structure, and mechanism of action of the Bacillus subtilis t-RNA synthetases in order to develop them as potential anti-bacterial agents.

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